Fig. 2

Oxygen-hemoglobin dissociation curve. Of note, conditions that shift the curve to the left (dashed red line: high pH, low temperature, low 2,3-diphosphoglicerate concentration) increase the oxygen affinity and the hemoglobin saturation, while conditions that shift the curve to the right (dashed light blue line: low pH, high temperature, high 2,3-diphosphoglicerate concentration) decrease the oxygen affinity and the hemoglobin saturation. p50, pressure at which hemoglobin is 50% saturated (27 mmHg on the X-axis within a normal representative oxygen-hemoglobin dissociation curve) [24]. On the Y-axis, we reported oxygen saturation expressed as %. On the X-axis, we reported arterial oxygen pressure expressed as mmHg