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  1. In recent decades, there has been an increase in life expectancy in children with life-limiting conditions. Ideally, parents and clinicians would work together to ensure the best care for these children. Sever...

    Authors: Karen Mackintosh and Paul McConnell
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:47
  2. Levosimendan has been reported to have a positive effect on ischemia–reperfusion injury. Herein, we aimed to evaluate the effects of levosimendan applied after reperfusion in an experimental intestinal injury-...

    Authors: Hakan Aygun, Cimen Olguner, Ugur Koca, Bekir Ugur Ergur, Ali Rıza Sisman, Duyguhan Isguven, Pelin Girgin, Muhammed Akkus and Serkan Tulgar
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:45
  3. Critical care ultrasonography (US) is widely used by intensivists managing critically ill patients to accurately and rapidly assess different clinical scenarios, which include pneumothorax, pleural effusion, p...

    Authors: Antonio Messina, Chiara Robba, Rita Bertuetti, Daniele Biasucci, Francesco Corradi, Francesco Mojoli, Silvia Mongodi, Eduardo Rocca, Stefano Romagnoli, Filippo Sanfilippo, Luigi Vetrugno and Gianmaria Cammarota
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:44
  4. Colorectal cancer is quite common, and surgery is the most effective treatment for most patients. However, postoperative pain management is generally inadequate in most patients. This study aimed to determine ...

    Authors: Ozgenur Kekul, Yasemin Burcu Ustun, Cengiz Kaya, Esra Turunç, Burhan Dost, Sezgin Bilgin and Fatih Ozkan
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:43
  5. Since January 2020, coronavirus disease 19 (COVID-19) has rapidly spread all over the world. An early assessment of illness severity is crucial for the stratification of patients in order to address them to th...

    Authors: Michela Rauseo, Marco Perrini, Crescenzio Gallo, Lucia Mirabella, Karim Mariano, Giuseppe Ferrara, Filomena Santoro, Livio Tullo, Daniela La Bella, Paolo Vetuschi and Gilda Cinnella
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:42
  6. In polytrauma intensive care unit (ICU) patients, glutamine (GLN) becomes a “conditionally essential” amino acid; its role has been extensively studied in numerous clinical trials but their results are inconcl...

    Authors: Antonella Cotoia, Leonarda Pia Cantatore, Renata Beck, Livio Tullo, Donatella Fortarezza, Flavia Marchese, Giuseppe Ferrara and Gilda Cinnella
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:41
  7. The current organizational structure of the Italian healthcare system does not include the institutionalization of clinical ethics services.

    Authors: Matteo Filippini, Federico Nicoli, Mario Picozzi and Nicola Latronico
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:40
  8. Upper airway surgery often poses a challenge to both anesthesiologists and surgeons, as airway access, mechanical ventilation, and surgical difficulties may occur in a tricky combination. To fulfill the need f...

    Authors: Alberto Grassetto, Tommaso Pettenuzzo, Flavio Badii, Francesca Barzaghi, Riccardo Carlon, Sandro Dellarole, Marilena Pipitone, Alessandra Versaci, Nicolò Sella, Marco Lionello and Andy Bertolin
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:39
  9. The coronavirus disease 2019 (COVID-19) pandemic has caused over 530 million infections to date (June 2022), with a high percentage of intensive care unit (ICU) admissions. In this context, relatives have been...

    Authors: Filippo Sanfilippo, Luigi La Via, Giovanni Schembari, Francesco Tornitore, Gabriele Zuccaro, Alberto Morgana, Maria Rita Valenti, Francesco Oliveri, Federico Pappalardo and Marinella Astuto
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:38
  10. Krebs von den Lungen 6 (KL-6) is a high-molecular-weight mucin-like glycoprotein, which is also known as MUC1. KL-6 is mainly produced by type 2 pneumocytes and bronchial epithelial cells, and, therefore, elev...

    Authors: Giuliana Scarpati, Daniela Baldassarre, Massimo Boffardi, Vincenzo Calabrese, Edoardo De Robertis, Graziella Lacava, Filomena Oliva, Pasquale Pagliano, Gabriele Pascale, Giovanni L. Tripepi and Ornella Piazza
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:37
  11. COVID‑19 is a novel cause of acute respiratory distress syndrome (ARDS) that leads patients to intensive care unit (ICU) admission requiring invasive ventilation, who consequently are at risk of developing of ...

    Authors: Nardi Tetaj, Alessandro Capone, Giulia Valeria Stazi, Maria Cristina Marini, Gabriele Garotto, Donatella Busso, Silvana Scarcia, Ilaria Caravella, Manuela Macchione, Giada De Angelis, Rachele Di Lorenzo, Alessandro Carucci, Maria Vittoria Antonica, Ilaria Gaviano, Carlo Inversi, Elisabetta Agostini…
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:36
  12. Critically ill, COVID-19 patients are characterized by a hypermetabolic state and a reduced food intake and are at high risk of malnutrition and lean body mass loss. An appropriate metabolic-nutritional interv...

    Authors: Romano Tetamo, Ciro Fittipaldi, Salvatore Buono and Michele Umbrello
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:35
  13. Carbapenem-resistant Gram-negative bacteria are frequent causes of sepsis and septic shock in intensive care unit (ICU) and thus considered a public health threat. Until now, the best available therapies consi...

    Authors: Andrea Cortegiani, Giulia Ingoglia, Mariachiara Ippolito, Massimo Girardis, Marco Falcone, Federico Pea, Francesco Pugliese, Stefania Stefani, Pierluigi Viale and Antonino Giarratano
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:34
  14. Several perioperative factors are responsible for the dysregulation or suppression of the immune system with a possible impact on cancer cell growth and the development of new metastasis. These factors have th...

    Authors: Etrusca Brogi and Francesco Forfori
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:33
  15. Significant concerns raise for the healthcare workers involved in airway management of patients diagnosed with coronavirus 2019 disease (COVID-19).

    Authors: Gilberto Duarte-Medrano, Massimiliano Sorbello, Rafael Renato Susunaga-Hope, Paula Ivette Fuentes-Castro, Beatriz C. Avila-OrtIz, Aida Paola Velasco-Godinez, Wendy Y. Contreras-Garcia, Miguel Alejandro Pineda-Castillo, Felipe Urdaneta and Félix Ignacio Téllez-Ávila
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:32
  16. An amplified and/or prolonged surgical stress response might overcome the organs’ functional reserve, thus leading to postoperative complications. The aim of this systematic literature review is to underline h...

    Authors: Iacopo Lanini, Timothy Amass, Caterina Scirè Calabrisotto, Sergio Fabbri, Silvia Falsini, Chiara Adembri, Alessandro Di Filippo, Stefano Romagnoli and Gianluca Villa
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:31
  17. Authors: Michela Rauseo, Elena Spinelli, Nicolò Sella, Douglas Slobod, Savino Spadaro, Federico Longhini, Antonino Giarratano, Gilda Cinnella, Tommaso Mauri and Paolo Navalesi
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:30

    The original article was published in Journal of Anesthesia, Analgesia and Critical Care 2022 2:28

  18. The appropriate timing of surgery and perioperative management of patients with previous SARS-CoV-2 infection are open issues. The purpose of this document is to support the clinical decision-making process re...

    Authors: Andrea Cortegiani, Vincenzo Francesco Tripodi, Carlo Alberto Castioni, Clelia Esposito, Nicola Galdieri, Roberta Monzani, Marco Rispoli, Alessandro Simonini, Vito Torrano, Antonino Giarratano and Angelo Gratarola
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:29
  19. Mechanical ventilation is a life-saving technology, but it can also inadvertently induce lung injury and increase morbidity and mortality. Currently, there is no easy method of assessing the impact that ventil...

    Authors: Michela Rauseo, Elena Spinelli, Nicolò Sella, Douglas Slobod, Savino Spadaro, Federico Longhini, Antonino Giarratano, Cinnella Gilda, Tommaso Mauri and Paolo Navalesi
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:28

    The Correction to this article has been published in Journal of Anesthesia, Analgesia and Critical Care 2022 2:30

  20. Endotoxin (ET) removal therapy with polymyxin B-immobilized fiber column hemoperfusion (PMX-HP) has been used for the treatment of septic shock. Some observational studies reported clinical benefits, particula...

    Authors: Hisataka Shoji and Ricard Ferrer
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:27
  21. Here, we describe the case of a 39-year-old woman with cystinosis who already suffered from an extra parenchymal pattern of restrictive lung disease and, after SARS-CoV-2-related respiratory failure, had a dif...

    Authors: Luigi Vetrugno, Valentina Angelini, Simone Antonio Smiraglia, Elisabetta Saraceni, Pierluigi Di Giannatale and Salvatore Maurizio Maggiore
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:26
  22. Endoscopic treatment for achalasia (POEM) is a recently introduced technique that incorporates the concepts of natural orifice transluminal surgery. Although pediatric achalasia is rare, POEM has been episodic...

    Authors: Fabio Sbaraglia, Pietro Familiari, Federica Maiellare, Marco Mecarello, Annamaria Scarano, Demetrio Del Prete, Rosa Lamacchia, Federica Antonicelli and Marco Rossi
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:25
  23. In order to systematically review the latest evidence on anesthesia, intraoperative neurologic monitoring, postoperative heparin reversal, and postoperative blood pressure management for carotid endarterectomy...

    Authors: Sergio Bevilacqua, Giulia Ticozzelli, Massimiliano Orso, Giuseppe Alba, Laura Capoccia, Alessandro Cappelli, Carlo Cernetti, Marina Diomedi, Walter Dorigo, Gianluca Faggioli, Giovanni Giannace, David Giannandrea, Matteo Giannetta, Gianfranco Lessiani, Enrico Maria Marone, Daniela Mazzaccaro…
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:24
  24. The ratio between arterial blood partial pressure of oxygen and fraction of inspired oxygen (PaO2/FiO2) was largely used for grading and managing the respiratory failure in non-mechanically ventilated COVID-19. I...

    Authors: Ilenia Gatto, Emanuela Biagioni, Irene Coloretti, Serena Viappiani, Stefano Busani and Massimo Girardis
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:23
  25. The use of extracorporeal carbon dioxide removal (ECCO2R) is less invasive than extracorporeal membrane oxygenation (ECMO), and intraoperative control of gas exchange could be feasible. The aim of this study in i...

    Authors: Franco Ruberto, Francesco Alessandri, Mario Piazzolla, Veronica Zullino, Katia Bruno, Paola Celli, Daniele Diso, Federico Venuta, Federico Bilotta and Francesco Pugliese
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:22
  26. Questions remain on the optimal management of subarachnoid hemorrhage (SAH) patients once they are admitted to the referring center, before and after the aneurysm treatment. To address these issues, we created...

    Authors: Edoardo Picetti, Andrea Barbanera, Claudio Bernucci, Alessandro Bertuccio, Federico Bilotta, Edoardo Pietro Boccardi, Tullio Cafiero, Anselmo Caricato, Carlo Alberto Castioni, Marco Cenzato, Arturo Chieregato, Giuseppe Citerio, Paolo Gritti, Luigi Lanterna, Roberto Menozzi, Marina Munari…
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:21
  27. Assess long-term quality of life (HR-QoL) and socio-economic impact in COVID-19-related ARDS (C-ARDS) survivors.

    Authors: Michele Umbrello, Sara Miori, Andrea Sanna, Sergio Lassola, Elena Baruzzo, Daniele Penzo, Giovanni Pedrotti, Annamaria Perino, Angelo Colombo, Rocco Pace and Sandra Magnoni
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:20
  28. Spinal anesthesia (SA) is widely used for anesthetic management of patients undergoing hip surgery, and hypotension is the most common cardiovascular side effect of SA. This paper aims to assess the lowest eff...

    Authors: Antonio Messina, Luigi La Via, Angelo Milani, Marzia Savi, Lorenzo Calabrò, Filippo Sanfilippo, Katerina Negri, Gianluca Castellani, Gianmaria Cammarota, Chiara Robba, Emanuela Morenghi, Marinella Astuto and Maurizio Cecconi
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:19
  29. Cardiac complications in patients with COVID-19 have been described in the literature with an important impact on outcome. The primary objective of our systematic review was to describe the kind of cardiac com...

    Authors: E. Brogi, F. Marino, P. Bertini, G. Tavazzi, F. Corradi and F. Forfori
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:18
  30. Arterial hypotension is common in patients during surgery and those admitted to the intensive care unit (ICU) postoperatively. Perioperative arterial hypotension reportedly significantly affects surgical patie...

    Authors: Fabio Guarracino and Pietro Bertini
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:17
  31. The manuscript describes a case report of 2 prolonged prone position cycles (72 h each) of a coronavirus disease 2019 pneumonia in an intubated pregnant woman (at 22 weeks of gestational age), being successful...

    Authors: Federico Linassi, Matteo Campagnolo, Enrico Busato, Valentina Ortolani and Mario Peta
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:16
  32. Sepsis and COVID-19 are two clinical conditions that can lead to a dysregulated inflammatory state causing multiorgan dysfunction, hypercytokinemia, and a high risk of death. Specific subgroups of critically i...

    Authors: Juan Carlos Ruiz-Rodríguez, Erika P. Plata-Menchaca, Luis Chiscano-Camón, Adolf Ruiz-Sanmartin and Ricard Ferrer
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:15
  33. Issues remain on the optimal management of subarachnoid hemorrhage (SAH) patients once they are admitted to the referring center, before and after the aneurysm treatment. To address these issues, we created a ...

    Authors: Edoardo Picetti, Andrea Barbanera, Claudio Bernucci, Alessandro Bertuccio, Federico Bilotta, Edoardo Pietro Boccardi, Tullio Cafiero, Anselmo Caricato, Carlo Alberto Castioni, Marco Cenzato, Arturo Chieregato, Giuseppe Citerio, Paolo Gritti, Luigi Lanterna, Roberto Menozzi, Marina Munari…
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:13
  34. Emergency settings in obese people require tailored multidisciplinary protocols and pathways to manage these complex patients. For this reason, we would like to foresee a proficient cooperation with the UK Soc...

    Authors: Ida Di Giacinto, Martina Guarnera, Clelia Esposito, Stefano Falcetta, Gerardo Cortese, Giuseppe Pascarella, Massimiliano Sorbello and Rita Cataldo
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:12
  35. Since the appearance of the first report on postoperative cognitive impairment in 1955, the number of papers focusing on perioperative neurocognitive disorders (PND) has constantly increased, both in the field...

    Authors: Gianluca Villa, Lorenzo Foti, Tessa Piazzini, Gaetano Russo, Marin Verrengia, Corinne Sangermano, Federico Bilotta and Stefano Romagnoli
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:11
  36. During the COVID-19 pandemia, non-invasive mechanical ventilation (NIV) has been largely applied. Few data are available about predictors of NIV failure in critical COVID-19 patients admitted to ICU. The aim o...

    Authors: Antonio Romanelli, Pietro Toigo, Giuliana Scarpati, Angela Caccavale, Gianluigi Lauro, Daniela Baldassarre, Filomena Oliva, Graziella Lacava, Gabriele Pascale and Ornella Piazza
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:10
  37. We aim to develop evidence-based recommendations for intensivists caring for children admitted to intensive care units and requiring analgesia and sedation. A panel of national paediatric intensivists expert i...

    Authors: Angela Amigoni, Giorgio Conti, Alessandra Conio, Manuela Corno, Paola Claudia Fazio, Federica Ferrero, Marta Gentili, Cristina Giugni, Manuela L’Erario, Maristella Masola, Paola Moliterni, Giuseppe Pagano, Zaccaria Ricci, Stefano Romagnoli, Beatrice Vasile, Francesca Vitale…
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:9
  38. Opioids are frequently used in the postoperative period due to their analgesic properties. While these drugs reduce nociceptive somatic, visceral, and neuropathic pain, they may also lead to undesirable effect...

    Authors: Alessandro De Cassai, Federico Geraldini, Serkan Tulgar, Ali Ahiskalioglu, Edward R. Mariano, Burhan Dost, Pierfrancesco Fusco, Gian Marco Petroni, Fabio Costa and Paolo Navalesi
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:8
  39. The aim of this document is to support clinical decision-making concerning positioning and mobilization of the critically ill patient in the early identification and resolution of risk factors (primary prevent...

    Authors: Mariachiara Ippolito, Andrea Cortegiani, Gianni Biancofiore, Salvatore Caiffa, Antonio Corcione, Gian Domenico Giusti, Pasquale Iozzo, Alberto Lucchini, Paolo Pelosi, Gabriele Tomasoni and Antonino Giarratano
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:7
  40. Local anesthesia is the most used anesthetic technique for inguinal hernia repair, despite its unpredictability. Selective spinal anesthesia with a short-term local anesthetic guarantees rapid recovery, predic...

    Authors: Fabio Costa, Giuseppe Pascarella, Paolo Luffarelli, Alessandro Strumia, Gaspare Biondo, Chiara Piliego, Rossana Alloni and Felice E. Agrò
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:6
  41. The inodilator levosimendan, in clinical use for over two decades, has been the subject of extensive clinical and experimental evaluation in various clinical settings beyond its principal indication in the man...

    Authors: M. Girardis, D. Bettex, M. Bojan, C. Demponeras, S. Fruhwald, J. Gál, H. V. Groesdonk, F. Guarracino, J. L. Guerrero-Orriach, M. Heringlake, A. Herpain, L. Heunks, J. Jin, D. Kindgen-Milles, P. Mauriat, G. Michels…
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:4
  42. Airway management for thoracic surgery represents a high risk setting for SARS-CoV-2 infection diffusion due to complex and invasive airway instrumentation and techniques.

    Authors: Marco Rispoli, Federico Piccioni, Ida Di Giacinto, Gerardo Cortese, Stefano Falcetta, Domenico Massullo, Silvia Fiorelli, Ivana Zdravkovic, Cecilia Coccia, Giulio Rosboch, Antonio Corcione and Massimiliano Sorbello
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:3
  43. Risk stratification plays a central role in anesthetic evaluation. The use of Big Data and machine learning (ML) offers considerable advantages for collection and evaluation of large amounts of complex health-...

    Authors: Valentina Bellini, Marina Valente, Giorgia Bertorelli, Barbara Pifferi, Michelangelo Craca, Monica Mordonini, Gianfranco Lombardo, Eleonora Bottani, Paolo Del Rio and Elena Bignami
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:2
  44. After the COVID-19 pandemic outbreak in March 2020, the majority of hospital policies have followed guidelines aimed to prevent the virus transmission and the families’ entry was denied in all hospital wards a...

    Authors: Annalaura Ferrari, Selena Russo, Catia Quagliotto, Roberta Granello, Lorenza Menato, Antonio Nola, Stefano Addesa, Sergio Cassella, Antonio Farnia, Mariagrazia Strepparava, Alessandra Mauri and Mario Peta
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2022 2:1
  45. Goal-directed therapy (GDT) aims to assure tissue perfusion, by optimizing doses and timing of fluids, inotropes, and vasopressors, through monitoring of cardiac output and other basic hemodynamic parameters. ...

    Authors: Mariateresa Giglio, Giandomenico Biancofiore, Alberto Corriero, Stefano Romagnoli, Luigi Tritapepe, Nicola Brienza and Filomena Puntillo
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2021 1:26
  46. Life-threatening streptococcal sepsis nowadays represents an uncommon event in previously healthy infants and children. Critically ill patients suffering from severe streptococcal sepsis complications may pres...

    Authors: M. Piastra, V. Ferrari, E. Picconi, T. C. Morena, L. Pezza, G. De Rosa, M. C. Fedele, O. Genovese, R. Onesimo, A. Tempera, P. Valentini, D. Buonsenso, F. Visconti, G. Zito, C. Benassi and G. Conti
    Citation: Journal of Anesthesia, Analgesia and Critical Care 2021 1:24