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Table 5 Time from administration of reversal agents to recovery of TOFR to 0.7, 0.8, 0.9, and 1.0 in patients with a deep/moderate or shallow/minimal block

From: Decurarization After Thoracic Anesthesia using sugammadex compared to neostigmine (DATA trial): a multicenter randomized double-blinded controlled trial

 

Neostigmine group (n = 34)

Sugammadex group (n = 36)

p-value

Deep/moderate block subgroup

 Recovery of TOFR to 0.9

  Number of patients

15 (100%)

21 (100%)

 

  Median (IQR), s

420 (246–896)

115 (78–180)

 < 0.001

Recovery of TOFR to 1.0

 Number of patients

9 (88.2%)

16 (80.6%)

 

 Median (IQR), s

472 (306–688)

151 (101–208)

 < 0.001

Time to extubation

 Median (IQR), min

23 (17–43)

12 (7–15)

0.004

Time to discharge to the ward

 Median (IQR), min

93 (85–109)

102 (76–123)

0.362

 Recovery of TOFR to 0.9 within 5 min from reversal administration

5 (33.3%)

19 (90.5%)

0.001

 Recovery of TOFR to 0.9 within 10 min from reversal administration

10 (66.7%)

21 (100%)

0.008

 Recovery of TOFR to 1.0 within 10 min from reversal administration

7 (53.8%)

21 (100%)

0.001

Shallow/minimal block subgroup

 Recovery of TOFR to 0.9

  Number of patients

19 (88.2%)

15 (75.0%)

 

  Median (IQR), s

184 (121–300)

44 (35–80)

 < 0.001

Recovery of TOFR to 1.0

 Number of patients

9 (100%)

15 (100%)

 

 Median (IQR), sec

229 (119–452)

86 (41–140)

0.003

 Recovery of TOFR to 0.9 within 5 min from reversal administration

15 (78.9%)

15 (100%)

0.084

 Recovery of TOFR to 0.9 within 10 min from reversal administration

16 (84.2%)

15 (100%)

0.162

 Recovery of TOFR to 1.0 within 10 min from reversal administration

13 (72.2%)

15 (100%)

0.036

Time to extubation

 Median (IQR), min

13.2 (8.6–20.6)

11.1 (8.2–15)

0.011

Time to discharge to the ward

 Median (IQR), min

89 (62–119)

84 (75–101)

0.572

  1. TOFR Train-of-four ratio