High versus standard blood pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: a study protocol for the HISTAP randomized clinical trial

Table 1 Studies evaluated for sample size calculation

Authors	Patients (n)		Mortality (n)		Events (n) (overall)		Major events (n) (overall)
Authors	Case	Control	Case	Control	Case	Control	Case	Control
Brandstrup et al. [23]	72	69	0	4	21	40	8	18
Gao et al. [24]	86	93	2	4	46	84	18	23
Abraham-Nordling et al. [25]	82	79	NA	NA	50	81	22	39
Kalyan et al. [26]	121	118	2	4	102	115	46	46
Jie et al. [27]	96	89	0	0	60	97	19	21
Grant et al. [28]	164	166	1	1	96	100	35	46
Myles et al. [29]	1493	1490	96	95	823	676	549	437
Wuethrich et al.	83	83	0	0	77	161	16	29
Benes et al. [30]	60	60	1	2	32	73	13	41
Pearse et al. [31]	62	60	6	7	43	90	28	47
Pearse et al. [32]	368	366	12	11	134	158	342	349
Futier et al. [22]	149	146	9	8	169	210	56	75

ISSN: 2731-3786