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Table 2 Hemodynamic parameters at baseline (start of resuscitation) and post-resuscitation, at the first TPTD determination

From: Subclinical cardiac dysfunction may impact on fluid and vasopressor administration during early resuscitation of septic shock

 

Cardiac Dysfunction (CFI ≤ 4.5 min–1)

Normal Cardiac Function (CFI > 4.5 min–1)

Patients – no. (%)

17 (42)

23 (58)

 

Baseline (resuscitation start)

Post-resuscitation (5–6 h from baseline)

Baseline (resuscitation start)

Post-resuscitation (5–6 h. from baseline)

CFI (min −1)

3.6 ± 0.7#

6.6 ± 1.9 #

CI (L/min/m2)

2.2 ± 0.6#

3.6 ± 0.9 #

GEDVI (mL/m2)

609 ± 126#

562 ± 121#

SVRI (dyn*s*cm−5*m2)

2721 ± 860#

1532 ± 480 #

EVLWI (ml/kg)

9.0 [8.0–11.6]

9.0 [7.3–11.0]

PVPI

2.2 ± 0,6#

2.4 ± 0.9 #

HR (bpm)

98.5 ± 15.7#

89.9 ± 16.5#*

98.4 ± 20.1#

93.1 ± 18.5#

MAP (mmHg)

61.2 ± 4.4#

80.1 ± 6.4 *

60.1 ± 3.7#

75 ± 5.5 *#

CVP (mmHg)

11.1 ± 3.9#

10.4 ± 5.1#

PaO2 (mmHg)

 

109 ± 19

111 ± 19

FiO2 (%)

 

72 ± 18

72 ± 19

PaO2/FiO2

 

162 ± 60

161 ± 39

(v-a) PCO2 (mmHg)

5 ± 1.8

3.4 ± 1 #

ScvO2 (%)

72.9 ± 10.8#

81.2 ± 7.0 #

Lac (mmol/L)

4.5 [2.8–7.4]

4.4 [3.1–7.6]

3.7 [2.7–5.7]

3.0 [2.0–4.3]

  1. Data are expressed as mean ± standard deviation or median [interquartile range], as appropriate
  2. * p < 0.05 versus baseline, within the same group
  3. #p < 0.05 versus post-resuscitation, between the two groups
  4. Abbreviations: CFI Cardiac Function Index, CI Cardiac index, GEDVI Global end-diastolic volume index, SVRI Indexed systemic vascular resistances, EVLWI Extra-vascular lung water index, PVPI Pulmonary vascular permeability index, HR Heart rate, MAP Mean arterial pressure, PaO2 Partial pressure of oxygen, FiO2 Inspiratory oxygen fraction, (v - a) PCO2 Central venous-arterial CO2 difference, ScvO2 Central venous oxygen saturation, Lac Arterial lactates, CVP Central venous pressure