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Table 2 Studies reported in the qualitative synthesis, highlighted in bold the main outcomes reported in the results

From: Risks and benefits of animal-assisted interventions for critically ill patients admitted to intensive care units

Author (Year) [ref.]

Setting

Study design

Timing

Animal experimented (patient number)

Control (patient number)

Outcome(s)

Results for the primary outcome

Interpretation of the finding

Miller (2003) [7]

Open-heart surgery

QES

Hospital discharge

Dog (17)

Usual care (13)

Discharge teaching

11/17 dog 10/13 usual care

Not beneficial

Cole (2007) [8]

Advanced heart failure

RCT

Hospital stay

Dog (26)

Volunteer (25); usual care (25)

PCWP; Systolic PAP; PCWP; EPI & NE levels; anxietya

Adjusted mean difference (SD), P dog vs volunteer − 3.70 (1.06) .001

Beneficial

Calcaterra (2015) [9]

Pediatric surgery

RCT

Immediate post-surgery

Dog (20)

Usual care (20)

EEG beta-activity; DBP; HR; SpO2; HbO2; Pain

20/20 dog 0/20 usual care

Beneficial

Walden (2020) [10]

Pediatric heart transplant

Pre-postQES

Hospital stay

Dog (5)

Dog (5)

Time (mins), Distance (ft) walked

14.7 (9.6) no-dog 17.2 (10.3) dog

Beneficial

Branson (2020) [11]

ICU older patients (> 60 y/o)

RCT

Hospital stay

Dog (6)

Usual care (4)

Stress VAS; FAS; Salivary CRP, IL-1B, cortisol

Pre Med. Dog 3.5

Post Med. Dog 1

Pre Med. usual 5.5

Post Med. usual 5.5

Beneficial

Jennings (2021) [12]

PICU, CVICU hematology/oncology

RCT

Hospital stay

Dog (44)

Usual care (36)

Activity level; Mood; Salivary cortisol

Mean (SD) 5.2275 (13.205) dog 3.889 (11.282) usual care

Beneficial

  1. CVICU, Cardiovascular Intensive Care Unit; DBP, diastolic blood pressure; EEG, electroencephalogram; EPI, epinephrine; FAS, Faces Anxiety Scale; ft, feet; HbO2, cerebral prefrontal oxygenation; HR, heart rate; mins, minutes; NE, norepinephrine; PAP, pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; PICU, Pediatric Intensive Care Unit; QES, quasi-experimental study; RC, retrospective cohort study; RCT, randomized controlled trial; SpO2, oxygen saturation; y/o, year old; VAS, visual analog scale
  2. a Anxiety, sum score in units