Association between histamine 2 receptor antagonists and sepsis outcomes in ICU patients: a retrospective analysis using the MIMI-IV database

Table 2 Subgroup analysis of the relationship between H2RA use and mechanical ventilation status and mortality and length of stay outcomes

	Baseline group No H2RA, no IMV (N = 12,058)	Group 1 No H2RA, IMV (N = 5625)	Group 2 H2RA, no IMV (N =4499)	Group 3 H2RA, IMV (N = 8409)	Total (N = 30,591)	p value
Mortality						< 0.001
Survived	10,823 (89.8%)	4198 (74.6%)	4196 (93.3%)	7089 (84.3%)	26,306 (86.0%)
Died	1235 (10.2%)	1427 (25.4%)	303 (6.7%)	1320 (15.7%)	4285 (14.0%)
Median ICU LOS (IQR)	1.9 (1.1–3.2)	2 (1.2–3.2)	4.6 (2.4–8.9)	4.7 (2.2–10)
Mean ICU LOS (SD)	2.6 (2.4)	6.9 (7.2)	2.8 (2.7)	7.8 (9.4)		< 0.001

Definitions: Baseline group patients not on H2RAs who were not ventilated, Group 1 patients not on H2RAs who were ventilated, Group 2 patients on H2RAs who were not ventilated and Group 3 patients on H2RAs who were ventilated

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