Table 1 Six questions to assess a guideline’s trustworthiness

(1) Are the recommendations clear?

(2) Have the panelists considered all alternatives?

(3) Have the panelists considered all patient-important outcomes?

(4) Is the recommendation based on an up-to-date systematic review?

(5) Is the strength of the recommendation compatible with the certainty of the evidence?

(6) Might conflicts of interest influence the recommendations? If yes, were they managed?