Table 5 Total dose of drugs given in the 48 h before extubation among critically ill patients with intellectual disability versus matched patients without intellectual disability

Propofol 0–24 h prior to extubation, Mean±SD

[median; IQR; min–max]

1.5 ± 1 [1.5; 0.6–1.9; 0.3–3.3]

2.1 ± 1 [1.9; 1.4–2.3; 0.4–6.2]

0.034

1.72, 2.4

Propofol 24–48 h prior to extubation, Mean±SD

[median; IQR; min–max]

1.4± 0.6 [1.32; 0.8–1.9; 0.4–2.4]

2.1 ± 1.1 [2.1; 1.2–2.5;

0.4–4.9]

0.009

1.7, 2.6

Midazolam 0–24 h prior to extubation, Mean ±SD

[median; IQR; min–max]

None given

0.12 ± 0.1 [0.09; 0.04–0.2; 0.03–0.33]

0.889

0.04-0.21

Midazolam 24–48 h prior to extubation, Mean±SD

[median; IQR; min–max]

None given

0.08 ± 0.07 [0.05; 0.03 − 0.1; 0.02–0.2]

0.571

0.005, 0.15

Morphine 24–48 h prior to extubation, Mean±SD

[median; IQR; min–max]

None given

None given

Fentanyl 0–24 h prior to extubation, Mean ±SD

[median; IQR; min–max]

0.02 ± 0.04 [0.001; 0.0007–0.05; 0–0.1]

0.02 ± 0.28 [0.002; 0.0008–0.003; 0–1.05]

0.672

-0.05, 0.26

Fentanyl 24–48 h prior to extubation, Mean ±SD

[median; IQR; min–max]

0.06 ± 0.1 [0.002; 0.001–0.003; 0–0.2]

0.003 ± 0.001 [0.003; 0.001− 0.003; 0–0.1]

1

0.002, 0.004

Remifentanil 0–24 h prior to extubation, Mean±SD

[median; IQR; min–max]

0.01± 0.02 [0.006; 0.003 − 0.009; 0–0.08]

0.01 ± 0.01 [0.008; 0.004–0.01; 0–0.06]

0.331

0.005, 0.015

Remifentanil 24–48 h prior to extubation, Mean ±SD

[median; IQR; min–max]

0.006 ± 0.003 [0.007;0.005 − 0.001; 0–0.01]

0.008 ± 0.003 [0.007; 0.005–0.01; 0–0.01]

0.516

0.006,0.009

Dexmedetomidine 24–48 h prior to extubation, Mean ±SD

[median; IQR; min–max]

None given

0.4 ± 0.13 [0.4; 0.2–0.4; 0.3–0.5]

0.5

− 0.95, 1.64

Dexmedetomidine 0–24 h prior to extubation, Mean±SD

[median; IQR; min–max]

0.6 ± 0.3 [0.6; 0.35–0.9; 0.3–1]

0.6 ± 0.1 [0.6; 0.5–0.7; 0.5–0.7]

1

0.49, 0.69

Methadone 0–24 h prior to extubation, Mean±SD

[median; IQR; min–max]

44 ± 36.5 [30; 15–80; 10–100]

48.3 ± 43.4 [30; 12.5–50; 5–120]

0.898

14.93, 81.72

Methadone 24–48 h prior to extubation, Mean ±SD

[median; IQR; min–max]

48 ± 35.8 [60; 10–80; 10–85]

70 ± 36.5 [60; 32.5–67.5; 30–120]

0.530

36.22, 103.77

Clonex 0–24 h prior to extubation, Mean ±SD

[median; IQR; min–max]

0.91 ± 0.63 [1; 0.25–1; 0.25–1.5]

1.9 ± 1.7 [1; 0.75–1.9; 0.5–6]

0.209

0.66, 3.27

Clonex 24–48 h prior to extubation, Mean ±SD

[median; IQR; min–max]

None given

2.9 ± 1.7 [2.5; 1.5–4; 1.5–6]

0.286

1.11, 4.71

Quetiapine 0–24 h prior to extubation, Mean ±SD

[median; IQR; min–max]

187.5 ± 176.2 [112.5; 81.25–368.75; 75–450]

72.7 ± 36.1 [75 ; 37.5–93.8; 25–150]

0.106

48.44, 97.01

Quetiapine 24–48 h prior to extubation, Mean ±SD

[median; IQR; min–max]

133.8 ± 86.9 [112.5; 63.75–225; 60–250]

58.9 ± 47.2 [50; 15.6–75; 12.5–150]

0.190

15.3, 102.55

Clozapine 0–24 h prior to extubation, Mean ±SD

[median; IQR; min–max]

500 ± 141.4 [500; 400–600; 400–600]

None given

Clozapine 24–48 h prior to extubation, Mean±SD

[median; IQR; min–max]

500± 141.4 [500; 400–600; 400–600]

None given

Halidol 0–24 h prior to extubation, Mean ±SD

[median; IQR; min–max]

3.5 ± 2.1 [3.5, 2–3.5; 2–5]

20 ± 21.7 [10; 5–37.5; 5–60]

0.143

− 2.75, 42.75