Table 1 (abstract A124). Summary of the included studies. RCT; Ramdomized Controlled Trial; POS: Prospective Observational Study; K:Ketamine; MV: Mechanical Ventilation; PEEPi:Positive End Expiratory Pressure Intrinsic; Cdyn: Dynamic Compliance; Rsmax: Airway Resistance; PEFR: Peak Expiratory Flow Rate; Ppeak: Pressure Peak; FEV1: Forced Expiratory Volume in 1 second; PRAM: Pediatic Respiratory Assessment Measure; PIS: Pulmonary Index Score; CAS: Clinical Asthma Score
From: Abstracts of the ICARE 2022 76th SIAARTI National Congress
First author, year, Design | N of patients Age (range) | Inclusion Criteria | Ketamine dose(s) Comparison Dose | Outcomes Side effects |
|---|---|---|---|---|
Esmailian M, 2018, RCT | 92 48 years (34-62) | - | -K: bolus 0,3 mg/kg (16,3%), 0,4 mg/kg (15,2%), and 0,5 mg/kg (17,4%) -Placebo | PEFR before and 1 h after treatment. No side effects reported. |
Allen JY, 2005, RCT | 68 6 years (2-10) | PIS>8 | -K: bolus 0,2 mg/kg + infusion 0,5 mg/kg/h (2 h) -Placebo | PIS score at 0, 30, 60, 90, and 120 minutes. No side effects reported. |
Tiwari A, 2016, RCT | 48 48 months (16-144) | PRAM≥5 after 2 hour of standard therapy | -K: bolus 0,5 mg/kg (20 min) + infusion 0,6 mg/kg/h (3 h) -Aminophylline: 5 mg/kg bolus (20 min) + infusion 0,9 mg/kg/h (3 h) | ∆PRAM in the first 24 h, Hypertension, Tachycardia. No side effects reported |
Nedel W, 2020, RCT | 45 65 (51-79) | -Adults intubated for bronchospasm -Rsmax≥12 cmH2O/L/s | -K: bolus 2 mg/kg + infusion 2 mg/kg/h -Fentanyl: bolus 1 mcg/kg + infusion of 1 mcg/kg/h | Rsmax, Cdyn, PEEPi, duration of MV at baseline, 3h and 24 h. No side effects reported. |
Howton JC, 1996, RCT | 44 33 (26-40) | - | -K: bolus 0,1 mg/kg + infusion 0,5 mg/kg/h -Placebo | Respiratory rate, hemodynamic parameters, Borg Score, P/F ratio, FEV1 before and after treatment. Side effects reported. |
Petrillo TM, 2001, POS | 10 8 (5-16) | CAS>12 | -K: bolus 1 mg/kg + infusion 0,75 mg/kg/h (1 h) | CAS, vital signs, PEFR before K administration, within 10 min afetr K administration, and 1 h after infusion. Side effect reported. |
Heshmati F, 2003, POS | 11 30 (15-40) | - | K: bolus 1 mg/kg + infusion 1 mg/kg/h (2 h) | Ppeak, PaCO2, PaO2 before K administration, 15 min after administration and 2 h after infusion. No side effects reported. |