Characteristics | Total | VAP | No VAP | p value a |
---|---|---|---|---|
284 | 94 | 190 | ||
Age, median (IQR) | 66 (58–73) | 66.5 (57–73) | 66 (58–74) | 0.806 |
Male, n (%) | 203 (71.5) | 60 (63.8) | 143 (75.3) | 0.245 |
Female, n (%) | 81 (28.5) | 34 (36.2) | 47 (24.7) | 0.245 |
BMI, kg/m2, median (IQR) | 27.7 (25–31) | 28.2 (25.4–32.4) | 27.6 (25–30.5) | 0.134 |
SOFA score, median* (IQR) | 4.5 (3–7) | 6 (4–8) | 4 (3–7) | 0.007 |
APACHE II score, median* (IQR) | 12 (8–17) | 13 (9–19) | 11.5 (7–16) | 0.068 |
Comorbidities, n (%) | ||||
 Arterial hypertension | 156 (54.9) | 51 (54.3) | 105 (55.2) | 0.873 |
 Cardiovascular diseases | 66 (23.2) | 28 (29.8) | 38 (20.0) | 0.067 |
 Diabetes | 50 (17.6) | 17 (18.1) | 33 (17.3) | 0.897 |
 Obesity a | 100 (35.2) | 40 (42.5) | 60 (31.6) | 0.069 |
 Chronic renal disease b | 13 (4.6) | 5 (5.3) | 8 (4.2) | 0.675 |
 Chronic liver disease | 3 (1.0) | 3 (1.6) | 0 (0.0) | N.A |
 Chronic lung disease | 38 (13.4) | 16 (17.0) | 22 (11.6) | 0.206 |
 Previous neoplasm c | 14 (4.9) | 6 (6.4) | 8 (4.2) | 0.719 |
 Chronic neurological disorders | 29 (10.2) | 14 (14.9) | 15 (7.9) | 0.067 |
 Autoimmune diseases | 29 (10.2) | 8 (8.5) | 21 (11.0) | 0.507 |
 Other chronical diseases | 38 (13.4) | 12 (12.7) | 26 (13.7) | 0.831 |
Clinical characteristics | ||||
 Previous surgery in last month | 11 (3.9) | 4 (4.2) | 7 (3.7) | 0.815 |
 Previous hospitalization last 6 months | 21 (7.4) | 7 (7.4) | 14 (7.4) | 0.981 |
 Pre-ICU hospitalization, days | 6 (± 8.0) | 4.7 (± 5.5) | 6.6 (± 9.0) | 0.072 |
 Total days on mechanical ventilation | 26.9 (± 19.9) | 32.0 (± 18.6) | 24.3 (± 20.0) | 0.002 |
 ICU length of stay, days | 29.3 (± 19.8) | 33.4 (± 18.4) | 27.3 (± 20.2) | 0.015 |
 Renal placement therapy, no. (%) | 27 (9.5) | 11 (11.7) | 16 (8.4) | 0.835 |
 Barotrauma, no. (%) | 19 (6.7) | 4 (4.3) | 15 (7.9) | 0.250 |
 Pronation d | 109 (38.4) | 32 (34) | 77 (40.5) | 0.282 |
 Blood transfusion | 104 (36.2) | 45 (47.8) | 59 (31.0) | 0.006 |
 Tocilizumab/Sarilumab | 56 (19.5) | 26 (27.6) | 30 (15.8) | 0.018 |
 Pre-OTI antibiotic therapy e | 149 (51.9) | 55 (58.5) | 94 (49.5) | 0.152 |
Outcome | ||||
 ICU discharged, patients, no. % | 164 (57.8) | 50 (53.2) | 114 (60.0) | 0.276 |
 ICU mortality, patients, no. % | 120 (42.2) | 44 (46.8) | 76 (40.0) | 0.276 |
 30-day mortality, no. % | 104 (36.6) | 35 ((37.2) | 69 (36.3) | 0.880 |
 60-day mortality, no. % | 119 (41.9) | 43 (45.7) | 76 (40) | 0.358 |