Table 2 Cefiderocol doses adjusted on kidney function

Augmented^a

CG-CLCR, > 120 ml/min

2 g every 6 h, 3-h infusion

Normal

MDRD-eGFR, 90–120 ml/min/1.73 m²

2 g every 8 h, 3-h infusion

Mildly compromised

MDRD-eGFR, 60–90 ml/min/1.73 m²

2 g every 8 h, 3-h infusion

Moderately compromised

MDRD-eGFR, 30–60 ml/min/1.73 m²

1.5 g every 8 h, 3-h infusion

Critically compromised

MDRD-eGFR, 15–30 ml/min/1.73 m²

1 g every 8 h, 3-h infusion

End-stage renal disease

MDRD-eGFR, < 15 ml/min/1.73 m²

0.75 g every 12 h, 3-h infusion

Intermittent dialysis required

0.75 g every 12 h, 3-h infusion, (3rd) supplementary dose 0.75 g after hemodialysis (during hemodialysis days)

CRRT required

◦ ≤ 2 l/h

⇒ 1.5 g every 12 h

◦ 2.1–3 l/h

⇒ 2 g every 12 h

◦ 3.1–4 l/h

⇒ 1.5 g every 8 h

◦ ≥4.1 l/h

⇒ 2 g every 8 h