Table 7 Characteristics and outcomes of retrieved trials for the outcome “Right ventricular dysfunction”
From: Cardiac complications in patients with COVID-19: a systematic review
Right ventricular dysfunction | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Authors | Age (years) all patients | Age (years) treatment group | Age (years) control group | Sex (M/F)+ | Cardiological comorbidities (n° pts) | Other comorbidities (n° pts) | COVID-19 severity | Morphological RV alterations (treatment-control or n° pts) | Systolic dysfunction (treatment-control or n° pts) | sPAP (treatment-control or n° pts) | Other no cardiac complications (n° pts) | Outcome (n° pts or cases - controls) |
Chen et al. [60] | 57.6 (44.9–70.3)§ | 56.1 ± 13.5 ° | 61.7 ± 9.6° | 36/18 | Hypertension (16) Diabetes (25) Coronary heart disease (6) | NA | Severe condition if: Respiratory distress, RR > 30 acts/min or SpO2 < 93% rest or P/F < 300 Critical condition if: Mechanical ventilation or shock or failure of other organs that requires intensive monitoring and treatment | Enlargement (0–2) | Failure (0–2) | Elevated (0–2) | AKI (18) | NA |
Deng et al. [62] | 65 (49–70.8)§ | 68 (57–77)§ | 56 (39–67)§ | 57/55 | Hypertension (36) Diabetes (19) Coronary heart disease (15) Atrial fibrillation (4) | COPD (4) | Severe patients if: Respiratory distress and RR> 30 acts/min or SpO2 < 93% or P/F < 300 Critical patients if: Respiratory failure with mechanical ventilation or shock or multi-organ failure that requires hospitalization in UTI | None | TAPSE < 16 mm (0-4) | NA | Mechanical ventilation (28) ECMO (3) | Death (14) Discharge (37) |
Dweck et al. [38] | 62 (52–71)§ | 64 (53–73)§ | 60 (51–69)§ | 844/365 | Hypertension (445) Diabetes (233) Ischemic heart disease (167) Heart failure (113) Valvular disease (80) | NA | Patients in critical care setting (ICU, coronary care unit, emergency room, cardiac catheter laboratory) | Dilated (181) | Mild to severe (313) | Elevated (99) | NA | NA |
Stӧbe et al. [36] | 64 ± 19.1° | 71 ± 15.2° | 41 ± 11.8° | 14/4 | Hypertension (13) Paroxysmal atrial fibrillation (4) Coronary artery disease (2) Dyslipidemia (4) Diabetes (5) Stroke (3) | Chronic kidney disease (7) COPD (1) | Severe symptoms: mechanical ventilation needed | NA | RV GLS mildly reduced (4-2) | None | Mechanical ventilation (14) | NA |
Szekely Y et al. [47] | 66.1 ± 17.3° | 65.9 ± 20° | 69.8 ± 16° | 63/37 | Hypertension (57) Ischemic heart disease (16) Congestive heart failure (7) Cerebrovascular disease (11) Atrial fibrillation (71) | Chronic renal disease (10) Diabetes (29) Obesity (29) Asthma (7) Malignancy (5) | Acuity score | Dilated (39) | RVFAC reduced 38.8 ± 11 (10) | NA | NA | NA |
Zeng et al. [44] | 63+ | NA | NA | 1/0 | Smoke (1) | Allergic cough (1) | NA | NA | Reduced TAPSE (1) | Elevated (1) | ARDS (1) CRRT (1) ECMO (1) Septic shock (1) | Death (1) |