Table 1 Characteristics and outcomes of retrieved trials
From: Cardiac complications in patients with COVID-19: a systematic review
Authors | Month/year of publication | Country | Study design | Primary outcome | Other outcomes | All patients | No. of treatment/control | Inclusion criteria | Exclusion criteria | Quality of evidences |
|---|---|---|---|---|---|---|---|---|---|---|
Amaratunga et al. [11] | May 2020 | USA | Case series | To report sinus bradycardia as a potential manifestation of COVID-19 | -Association between heart rate and temperature/blood pressure/oxygen saturation -Association between heart rate and medication | 4 | NA | NA | NA | NA |
Arentz et al. [12] | March 2020 | USA | Case series | To describe the clinical presentation, characteristics, and outcomes of patients COVID-19 admitted in Evergreen Hospital’s ICU | NA | 21 | NA | NA | NA | NA |
Bangalore et al. [13] | April 2020 | USA | Case series | To describe clinical experience | Electrocardiographic evidence | 18 | 8/10 | Patients with STEMI | NA | NA |
Barton et al. [14] | June 2020 | USA | Case series: autopsy | To share observations on COVID-19, based on 2 autopsies | To share experience on precautions and equipment to perform autopsies | 2 | NA | -Patients not treated for COVID-19 -Not tested patients before death | NA | NA |
Cao et al. [15] | March 2020 | China | Retrospective | To describe therapies, clinical and laboratory characteristics, and short-term outcomes of COVID-19 patients admitted in ICU | NA | 102 | 18–84 | Patients with COVID-19 hospitalized in Wuhan University Zhongnan Hospital between January 3 and February 1, 2020 | NA | 7# |
Chen et al. [16] | May 2020 | China | Retrospective | To identify how COVID-19 damages the cardiovascular system, at the level myocardial, conduction system, heart function, and blood pressure, especially in severe cases | To highlight potential risk factors for the severity of COVID-19 | 54 | NA | Severe and critical clinical cases, hospitalized in Zhongshan hospital between January 27 and February 28, 2020 | NA | 7# |
Chen et al. [17] | May 2020 | China | Retrospective | Comparing the demographic, clinical, laboratory, and radiological characteristics of patients with different clinical outcomes | NA | 274 | 113–161 | Patients, admitted to the Tonji Hospital between January 13 and February 12, 2020, who died or discharged until February 28, 2020 | NA | 7# |
Dabbagh et al. [18] | April 2020 | USA | Case report | Description of a clinical case | NA | 1 | NA | NA | NA | NA |
Deng et al. [19] | April 2020 | China | Retrospective | To investigate COVID-19 patients’ clinic and therapy, focusing on heart condition | To provide information about possible myocarditis or myocardial injury caused by COVID-19 | 112 | 45/67 | Patients admitted between January 6 and February 20, 2020, diagnosed with COVID-19 at Renmin Hospital in Wuhan | NA | 7# |
Dominguez-Erquicia et al. [20] | May 2020 | Spain | Case Report | Report | NA | 1 | NA | NA | NA | NA |
Doyen et al. [21] | April 2020 | France | Clinical case | Report | NA | 1 | NA | NA | NA | NA |
Du et al. [22] | April 2020 | China | Retrospective | Retrospective | Describe clinical features | 85 | NA | All consecutive patients with severe COVID-19 admitted to Hannan Hospital and Wuhan Union Hospital, between January 9 and February 15, 2020 | NA | 7# |
Du et al. [23] | April 2020 | China | Multicenter observational study | To describe hospitalization and critical care of patients who died of COVID-19 pneumonia | NA | 109 | 51/58 | NA | NA | 7# |
Dweck et al. [24]. | September 2020 | UK | International survey | To improve knowledge about cardiac manifestations of COVID-19 | To find patients who would benefit most from echocardiography | 1216 | 667/549 | Patients with confirmed or a high probability of COVID-19 with collected transthoracic echocardiogram in hospital setting from April 3 to April 20, 2020 | Not available data | 7# |
Guo et al. [25] | July 2020 | China | Retrospective | To investigate the association between cardiovascular disease and myocardial injury with fatal outcomes | NA | 187 | 135/52 | Patients with a diagnosis of COVID-19, according to the guidance of WHO, admitted to the Seventh Hospital of Wuhan City, China, from January 23 to February 23, 2020 | Incomplete data | 7# |
Hu et al. [26] | March 2020 | China | Case report | Helpful in treating similar patients | NA | 1 | NA | NA | NA | NA |
Huang et al. [27] | January 2020 | China | Report of data | To describe epidemiological, clinical, laboratory, and radiological characteristics, treatment, and outcomes of patients confirmed with COVID-19 | To compare ICU and non-ICU patients | 41 | 13/28 | Patients with laboratory-confirmed COVID-19 infection by RT-PCR and next-generation sequencing | NA | 7# |
Hussain et al. [28] | June 2020 | USA | Case report | Report | NA | 1 | NA | NA | NA | NA |
Inciardi et al. [29] | March 2020 | Italy | Case report | To describe the presentation of acute myocarditis in patients with COVID-19 | NA | 1 | NA | NA | NA | NA |
Kim HN et al. [30] | June 2020 | Korea | Case report | To present their first case of PCI for a patient with COVID-19 | NA | 1 | NA | NA | NA | NA |
Kim IC et al. [31] | April 2020 | Korea | Case report | Report | NA | 1 | NA | NA | NA | NA |
Kunal et al. [32] | November 2020 | India | Retrospective | To evaluate the cardiovascular complications and their impact on outcomes | NA | 108 | 28/80 | Symptomatic laboratory-confirmed COVID-19 | Asymptomatic patients No cardiac documentation | 7# |
Kuno et al. [33] | May 2020 | USA | Retrospective | To investigate the relation between cardiovascular disease and mechanical ventilation and mortality | NA | 8438 | NA | COVID-19 patients | NA | 6# |
Meyer et al. [34] | April 2020 | Switzerland | Case report | Description of Takotsubo case | NA | 1 | NA | NA | NA | NA |
Monmeneu et al. [35] | May 2020 | Spain | Case report | To provide evidence obtained with CMR of extensive myocardial involvement secondary to SARS-CoV-2 infection | NA | 1 | NA | NA | NA | NA |
Pascariello et al. [36] | June 2020 | Italy | Case report | To describe a case of cardiogenic shock due to COVID-19-related myocarditis | NA | 1 | NA | NA | NA | NA |
Paul et al. [37] | July 2020 | France | Case report | Report | NA | 1 | NA | NA | NA | NA |
Peigh et al. [38] | April 2020 | USA | Case series | To describe clinical characteristics, potential mechanisms, and outcomes of COVID-19 patients who develop de novo sinus node dysfunction | NA | 2 | NA | NA | NA | NA |
Ruan et al. [39] | March 2020 | China | Retrospective | To identify clinical predictors of mild and severe patient outcome | NA | 150 | 68/82 | NA | NA | 6# |
Sala et al. [40] | April 202 | Italy | Case report | Report | NA | 1 | NA | NA | NA | NA |
Seecheran et al. [41] | April 2020 | Trinidad and Tobago | Case report | Description | NA | 1 | NA | NA | NA | NA |
Shao et al. [42] | May 2020 | China | Retrospective | To describe COVID-19 progression and risk profiles for mortality in non-survivors | NA | 18 | NA | Patients died from 155 patients who met the criteria of COVID-19 clinical diagnosis based on the National Health Commission of China Guidelines (7th edition) | Patients discharged | 7# |
Shi et al. [43] | July 2020 | China | Retrospective cohort | To examine the association between cardiac injury and mortality | NA | 416 | 82/334 | Consecutive patients admitted to Renmin Hospital with confirmed COVID-19, according to WHP interim guidance | No record of cardiac markers | 7# |
Shi et al. [44] | May 2020 | China | Retrospective | To determinate the predictive value of myocardial injury markers on hospital death | To investigate features and potential causes of myocardial injury in severe COVID-19 patients | 671 | 106/565 | All patients admitted to Renmin Hospital of Wuhan University with confirmed severe COVID-19 | Cases with mild COVID-19, duplicated cases, and cases without available medical information | 7# |
Solano-Lopez et al. [45] | May 2020 | Spain | Case report | To describe a case of inverted Takotsubo | NA | 1 | NA | NA | NA | NA |
Stefanini et al. [46] | June 2020 | Italy | Retrospective | To evaluate the incidence, clinical presentation, angiography, and outcomes of STEMI in patients with COVID-19 | NA | 28 | NA | All patients with confirmed COVID-19 who underwent an urgent angiography because of STEMI between February 20 and March 30, 2020 | NA | 6# |
Szekely et al. [47] | July 2020 | Israel | Prospective | Comprehensive echocardiographic evaluation—frequency of cardiac abnormalities | Echocardiographic parameters stratified by troponin levels and clinical condition | 100 | NA | Consecutive patients hospitalized with COVID-19 patients | Echocardiographic evaluation not performed | 6# |
Stӧbe et al. | August 2020 | Germany | Observational study | To characterize the myocardial effects by echocardiography | NA | 18 | NA | Patients with SARS-CoV-2 admitted at Leipzing University Hospital and at Community Hospital Halle (Saale) in April 2020 | NA | 7# |
Tavazzi et al. [48] | April 2020 | Italy | Case report | To describe a case of myocardial biopsy to prove SARS-CoV-2 localization in myocardium | NA | 1 | NA | NA | NA | NA |
Villanueva et al. [49] | June 2020 | USA | Case report | To describe heart failure and arrhythmia as possible symptoms of COVID-19 | NA | 1 | NA | NA | NA | NA |
Wan et al. [50] | July 2020 | China | Retrospective | To describe the epidemiological and clinical features, laboratory and radiology findings, and outcomes of COVID-19 patients | NA | 135 | 95/40 | All patients with confirmed COVID-19 admitted to the Chongqing University Three Gorges Hospital from January 23 to February 8, 2020 | NA | NA |
Xie et al. [51] | August 2020 | China | Retrospective | To evaluate the effects of cardiovascular disease on COVID-19 | To evaluate laboratory and clinical characteristics of COVID-19 patients | 62 | 38/24 | All patients with confirmed COVID-19 admitted to the Hospital from February 15 to March 14, 2020 | Suspected diagnosis | 6# |
Xiong et al. [52] | October 2020 | China | Retrospective | To provide a recent description of clinical features of patients | To provide assistance in managing cardiovascular disorders in COVID-19 patients | 116 | 61/55 | Laboratory-confirmed COVID-19 admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020 | NA | 7# |
Yang et al. [53] | May 2020 | China | Retrospective | ICU mortality at 28 days | Incidence of ARDS and proportion of patients requiring mechanical ventilation | 52 | 20/32 | Critical ill patients admitted to Wuhan Jin Yin-tan Hospital from December 24, 2019, to January 26, 2020 | Admission after January 12, 2020, oxygen therapy with FiO2 < 60% | 7# |
Yu et al. [54] | May 2020 | China | Multicenter, prospective, observational study | Evaluation of outcomes and complications and intensity of treatment | NA | 226 | NA | All patients admitted in ICU from 8 AM of February 26, 2020, to 8 AM of the next day. The ICUs have to have closed adult units, at least 10 beds, full-time physicians and nurses | NA | 7# |
Zeng et al. [55] | April 2020 | China | Case report | Description | NA | 1 | NA | NA | NA | NA |
Zhang et al. [56] | June 2020 | China | Retrospective | To analyze epidemiological, clinical, laboratory, and radiological features of patients COVID-19 admitted in Zhongan Hospital of Wuhan University from January 2 to February 10, 2020 | NA | 221 | 55/166 | NA | NA | 7# |
Zhao et al. [57] | April 2020 | China | Retrospective | To explore the characteristics of patients with COVID-19 admitted to Jingzhou Central Hospital from January 16 to February 10, 2020 | NA | 91 | 30/61 | NA | NA | 7# |
Zhou et al. [58] | March 2020 | China | Retrospective, multicenter | To explore risk factors of in-hospital mortality | To describe clinical and laboratory courses during hospitalization | 191 | 54/137 | Adult patients with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital, discharged or died before January 31, 2020 | Patients still hospitalized or not confirmed by COVID-19 and without available data | 7# |