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Table 1 Research recommendations

From: Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit

Recommendation 1

R1

Studies on weaning from a prolonged infusion of dexmedetomidine

Recommendation 2

R2

Studies on the efficacy of drug rotation (analgesics or sedatives) protocols

Recommendation 4

R4.1

Studies on the prolonged infusion of ketamine

R4.2

Studies on efficacy and safety of other drugs used in difficult analgesia and sedation (i.e., sevoflurane)

Recommendation 5

R5

Studies on length of treatment with neuromuscular blocking agents

Recommendation 6

R6

Studies on continuous processed EEG in infants

Recommendation 7

R7.1

Studies on preventing and treatment of sleep disorders in paediatric intensive care unit

R7.2

Studies on monitoring the quality of sleep in paediatric intensive care unit with tools other than polysomnography

Recommendation 8

R8.1

Studies on the efficacy of alpha agonists in reducing the incidence of delirium in critically ill patients

R8.2

Studies on the impact of reduction of modifiable factors in paediatric delirium

Recommendation 9

R9

Studies on pharmacologic prevention and treatment of paediatric delirium

Recommendation 11

R11

Studies on weaning after ketamine and alpha agonists infusions

Recommendation 12

R12

Studies on preventing withdrawal syndrome from adopting strategies of weaning or pharmacologic strategies

Recommendation 15

R15

Studies describing characteristics of paediatric palliative sedation in children in intensive care unit

Recommendation 16

R16.1

Studies on pharmacological interactions between patient’s chronic therapy and analgesic and sedative treatment administered in intensive care unit

R16.2

Studies on the development of tools dedicated to children with developmental delay admitted to paediatric intensive care unit